Dicyanamide → 2-Methyl 3-(1-N-pyrrolidinyl-3-cyanopropyl)pyridine
反応式
C1(S([O-])(=O)=O)C=CC=CC=1.C(C[N+:14]1([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22]N=2)[CH2:18][CH2:17][CH2:16][CH2:15]1)#N.Br[CH2:27][CH2:28][C:29]#[N:30].[C:31](NC#N)#[N:32].[BH4-].[Na+]>C(O)C>[CH3:22][C:23]1[C:24]([CH2:25][CH2:20][CH:19]([N:14]2[CH2:15][CH2:16][CH2:17][CH2:18]2)[C:31]#[N:32])=[CH:27][CH:28]=[CH:29][N:30]=1参加物
6
実験手順
1-cyanomethyl-1-(2-picolyl)pyrrolidinium benzenesulfonate (see Preparation II) is rearranged and alkylated with 3-bromopropionitrile as in Example 2. The resulting dicyanoamine is decyanated with sodium borohydride in ethanol to give the product. Purification is effected via the picrate.
後処理
- customto give the product
- customPurification
出典と根拠
- ORDレコード
- ord-77ed0ada2d654ca3bda0d891202c6bc6
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04220781
反応ノート
読み込み中…