Hydrazine hydrate (1:1) → 3-Cyanobenzohydrazide
反応式
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]#[N:11])[CH:5]=1.O.[NH2:14][NH2:15]>C(O)C>[C:10]([C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([NH:14][NH2:15])=[O:2])#[N:11]参加物
4
実験手順
A mixture of 3-cyano-benzoic acid methyl ester (2 g, 12 mmol) and hydrazine monohydrate (0.60 mL, 12 mmol) in ethanol (10 mL) was stirred at room temperature overnight. The reaction mixture was concentrated and then the residue was triturated with diethyl ether to afford 3-cyano-benzoic acid hydrazide (1.02 g, 51%, pink solid). 1H NMR (DMSO) δ (ppm): 10.31 (s, 1H), 8.21 (m, 1H), 8.11 (m, 1H), 7.99 (m, 1H), 7.70 (m, 1H), 4.50 (s, 1H).
後処理
- concentrationThe reaction mixture was concentrated
- customthe residue was triturated with diethyl ether
出典と根拠
- ORDレコード
- ord-da855c96036c4c68ad18d2cc8a681244
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456200B2
反応ノート
読み込み中…