Diisopropylethylamine → Benzodiazepinesuccinamide

HRID 273285

反応式

HRID 273285 の反応式
[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[CH:4][CH:3]=[N:2]1.C([CH:15]([C:23]([NH2:25])=[O:24])[CH:16](CC=C)[C:17]([NH2:19])=[O:18])C=C.CCN(C(C)C)C(C)C>CN(C=O)C>[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[CH:4][C:3]([CH:15]([C:23]([NH2:25])=[O:24])[CH2:16][C:17]([NH2:19])=[O:18])=[N:2]1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 134664BenzodiazepineHCID 131723749HCID 131723749、化合物

生成物 1

HCID 136334626Benzodiazepinesuccinamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Following the procedures described for the synthesis of 11, diallylsuccinamide intermediate 16 was prepared from 14 in reasonable yield. 14 (2.59, 5.9 mmol), p-chloro-BZD (2.34 g, 6.2 mmol) and DIPEA (1 ml, 5.8 mmol) in 30 ml DMF was heated to 40-50 degree overnight.

後処理

  1. customwas prepared from 14 in reasonable yield

出典と根拠

ORDレコード
ord-2f787a2ae6ec41138582c97c2046094a
出典データセット
uspto-grants-2008_11
特許番号
US07456278B2

関連ノート

読み込み中…