Diisopropylethylamine → Benzodiazepinesuccinamide
反応式
[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[CH:4][CH:3]=[N:2]1.C([CH:15]([C:23]([NH2:25])=[O:24])[CH:16](CC=C)[C:17]([NH2:19])=[O:18])C=C.CCN(C(C)C)C(C)C>CN(C=O)C>[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[CH:4][C:3]([CH:15]([C:23]([NH2:25])=[O:24])[CH2:16][C:17]([NH2:19])=[O:18])=[N:2]1参加物
5
実験手順
Following the procedures described for the synthesis of 11, diallylsuccinamide intermediate 16 was prepared from 14 in reasonable yield. 14 (2.59, 5.9 mmol), p-chloro-BZD (2.34 g, 6.2 mmol) and DIPEA (1 ml, 5.8 mmol) in 30 ml DMF was heated to 40-50 degree overnight.
後処理
- customwas prepared from 14 in reasonable yield
出典と根拠
- ORDレコード
- ord-2f787a2ae6ec41138582c97c2046094a
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456278B2
反応ノート
読み込み中…