Sodium hydride → 2-chloro-N-(3-methylisoxazol-5-yl)methyl-N-(2,6-dimethylphenyl)acetamide

HRID 27338

反応式

HRID 27338 の反応式
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:13])=[O:4].[CH3:14][C:15]1[CH:19]=[C:18]([CH2:20]Cl)[O:17][N:16]=1.[H-].[Na+]>CN(C)C=O>[Cl:1][CH2:2][C:3]([N:5]([CH2:20][C:18]1[O:17][N:16]=[C:15]([CH3:14])[CH:19]=1)[C:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:13])=[O:4]

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 707982-Chloro-N-(2,6-dimethylphenyl)acetamideHCID 71314965-(Chloromethyl)-3-methyl-1,2-oxazole

生成物 1

HCID 130376032-chloro-N-(3-methylisoxazol-5-yl)methyl-N-(2,6-dimethylphenyl)acetamide収率 30%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 4.54 g N-chloroacetyl-2,6-dimethylaniline and 3 g 3-methyl-5-chloromethylisoxazole (prepared as in Example 8 above) in 100 ml dry dimethylformamide was treated with 1.33 g sodium hydride as in Example 3 above. After workup, the solid product was purified by column and high-pressure liquid chromatography to yield 2.0 g pure product, m.p. 78°-82° C. This product is shown as Compound 1 in Table I. C15H17ClN2O2 : calc., %C 61.54, %H 5.81, %N 9.57; found, %C, 63.37, %H 6.16, %N 9.65.

後処理

  1. customAfter workup, the solid product was purified by column and high-pressure liquid chromatography

出典と根拠

ORDレコード
ord-caf24c795a934682aa045ca65210c2ab
出典データセット
uspto-grants-1980_09
特許番号
US04221584

関連ノート

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