Hydrochloric Acid → 3-(Dimethylamino)-1-(furan-2-yl)propan-1-one--hydrogen chloride (1/1)
反応式
[C:1]([C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2].[ClH:9].[CH3:10][NH:11][CH3:12].[CH2:13]=O.Cl>C(O)C>[ClH:9].[CH3:10][N:11]([CH2:13][CH2:2][C:1]([C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)=[O:3])[CH3:12]参加物
6
実験手順
2-Acetylfuran (13.8 g), dimethylamine hydrochloride (13.3 g), paraformaldehyde (5.0 g) and ethanol (80 ml) acidified with concentrated HCl (1.0 ml) were stirred. Part of this mixture (27 ml) was pumped through the CMR (18 ml/min; 160°-70° C.; 500 kPa;) and the hot product collected in an ice-water cooled flask, to afford pale yellow crystals m.p. 172.5°-173° C. (cf lit.10 m.p. 173°-4° C.) in 13% yield.
後処理
- customwas pumped through the CMR (18 ml/min; 160°-70° C.; 500 kPa;)
- customthe hot product collected in an ice-water cooled flask
出典と根拠
- ORDレコード
- ord-46302bb0417e4d80803efc7bded4318f
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05387397
反応ノート
読み込み中…