5-[[3-(1,1-Dimethylethyl)-4-hydroxy-5-methylphenyl]methylene]-4-thiazolidinone → HCID 18936445、化合物
反応式
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([CH:13]=[C:14]2[S:18][CH2:17][NH:16][C:15]2=[O:19])[CH:8]=[C:9]([CH3:12])[C:10]=1[OH:11])([CH3:4])[CH3:3]>O1CCCC1.[Pd]>[CH3:4][C:2]([C:5]1[CH:6]=[C:7]([CH2:13][CH:14]2[S:18][CH2:17][NH:16][C:15]2=[O:19])[CH:8]=[C:9]([CH3:12])[C:10]=1[OH:11])([CH3:1])[CH3:3]参加物
4
実験手順
A solution of 0.28 g of the compound of Example 17 in 30 ml of tetrahydrofuran was hydrogenated at 60 pounds per square inch in the presence of 1.12 g of 5% palladium on carbon overnight at 60° C. The reaction mixture was filtered and evaporated to dryness. The resulting residue was dissolved in 3.5 ml of a 1:1.5 ethyl acetate/hexane solution and loaded onto a silica gel chromatography column. Elution with 40% ethyl acetate in hexane produced fractions which, upon evaporation to dryness, provided 0.05 g of title compound. m.p. 64°-68° C.