2-Nitrophenol → 2-Nitroanisole
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].[CH3:11]CCCCCCCC.CNC(=NC)C1C=CC=CC=1.C(=O)(OC)OC>CO>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH3:11])([O-:3])=[O:2]参加物
6
実験手順
10 mol of 2-nitrophenol was charged into a stirred, heated reactor, along with 800 ml of nonane and 5% N,N'-dimethylbenzoamidine, and the mixture was heated to 150° C. Then 12 mol of dimethyl carbonate was added portionwise over 5 hr. The methanol produced by the reaction was removed by distillation over a distillation column. After completion of the reaction, the reaction mixture was refined by distillation. 2-Nitroanisole was obtained in the amount of about 9 mol, corresponding to a yield of c. 90%, based on the starting amount of 2-nitrophenol.
後処理
- temperatureheated reactor
- customwas removed by distillation over a distillation column
- customAfter completion of the reaction
- distillationthe reaction mixture was refined by distillation
出典と根拠
- ORDレコード
- ord-323d01ddebbe403da32e604664b98523
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05387718
反応ノート
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