2-Nitrophenol → 2-Nitroanisole

HRID 273938

反応式

HRID 273938 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].[CH3:11]CCCCCCCC.CNC(=NC)C1C=CC=CC=1.C(=O)(OC)OC>CO>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH3:11])([O-:3])=[O:2]

参加物

6

反応物 4

HCID 69472-NitrophenolHCID 8141NonaneHCID 12021Dimethyl CarbonateHCID 185669Benzenecarboximidamide, n,n'-dimethyl-

生成物 1

HCID 70482-Nitroanisole

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

10 mol of 2-nitrophenol was charged into a stirred, heated reactor, along with 800 ml of nonane and 5% N,N'-dimethylbenzoamidine, and the mixture was heated to 150° C. Then 12 mol of dimethyl carbonate was added portionwise over 5 hr. The methanol produced by the reaction was removed by distillation over a distillation column. After completion of the reaction, the reaction mixture was refined by distillation. 2-Nitroanisole was obtained in the amount of about 9 mol, corresponding to a yield of c. 90%, based on the starting amount of 2-nitrophenol.

後処理

  1. temperatureheated reactor
  2. customwas removed by distillation over a distillation column
  3. customAfter completion of the reaction
  4. distillationthe reaction mixture was refined by distillation

出典と根拠

ORDレコード
ord-323d01ddebbe403da32e604664b98523
出典データセット
uspto-grants-1995_02
特許番号
US05387718

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