Hydrochloric Acid → HCID 23342859、化合物

HRID 27407ノート

反応式

HRID 27407 の反応式
[O:1]=[C:2]1[CH:6]([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:5][CH2:4][O:3]1.[OH-:13].[Na+].Cl.C(Cl)(Cl)Cl>O.C(O)C>[OH:3][CH2:4][CH2:5][CH:6]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[C:2]([OH:13])=[O:1]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 23342878HCID 23342878、化合物

生成物 1

HCID 23342859HCID 23342859、化合物収率 30.3%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

67.6 g (0.4 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone and 32 g (0.8 mol) of sodium hydroxide in 210 ml of water are heated for 2 hours under reflux, cooled and then acidified with hydrochloric acid to a pH value of 1. The reaction mixture is evaporated to dryness under reduced pressure and the residue taken up three times in benzene and evaporated in vacuo. The residue obtained is finally treated with a mixture of chloroform and ethanol (4:1 v/v) and the insoluble material filtered off. The filtrate is evaporated and the residue is recrystallized from ethanol. 22.7 g (yield: 30% of theory) of alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetic acid are obtained. M.P.: 123°-124° C.

後処理

  1. temperatureunder reflux
  2. temperaturecooled
  3. customThe reaction mixture is evaporated to dryness under reduced pressure
  4. customevaporated in vacuo
  5. customThe residue obtained
  6. filtrationthe insoluble material filtered off
  7. customThe filtrate is evaporated
  8. customthe residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-99b428fde9a147f19afbe43967e2b0bf
出典データセット
uspto-grants-1980_09
特許番号
US04221789

反応ノート

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