Benzo(d)thiazol-2-amine → 5-(Imidazo[2,1-b]benzothiazol-2-yl)-3-nitropyrocatechol

HRID 274471

反応式

HRID 274471 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([OH:15])[CH:6]=1)=O.[NH2:16][C:17]1[S:18][C:19]2[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=2[N:21]=1>C(O)C>[N:16]1[C:3]([C:5]2[CH:6]=[C:7]([OH:15])[C:8]([OH:14])=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=2)=[CH:2][N:21]2[C:20]3[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=3[S:18][C:17]=12

参加物

4

反応物 2

HCID 8706Benzo(d)thiazol-2-amineHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

生成物 1

HCID 214590695-(Imidazo[2,1-b]benzothiazol-2-yl)-3-nitropyrocatechol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1.95 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone, 1.06 g of 2-aminobenzothiazole and 50 ml of ethanol is heated to boiling under reflux for 17 hours. The reaction mixture is then cooled to room temperature, whereupon the crystals are removed by filtration under suction. There is obtained 5-(imidazo[2,1-b]benzothiazol-2-yl)-3-nitropyrocatechol of m.p. 303°-305° (from N,N-dimethylformamide/methanol).

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 17 hours
  3. customare removed by filtration under suction

出典と根拠

ORDレコード
ord-c6b1a535c5ee4613b184f2f0f99a485a
出典データセット
uspto-grants-1995_02
特許番号
US05389653

関連ノート

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