N-bromobutanimide → 1H-Pyrrole-2-carbonitrile, 1-[4-(bromomethyl)phenyl]-
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][CH:10]=[C:9]2[C:13]#[N:14])=[CH:4][CH:3]=1.[Br:15]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C1C(C(OO)=O)=CC=CC=1>[Br:15][CH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][CH:10]=[C:9]2[C:13]#[N:14])=[CH:4][CH:3]=1参加物
5
実験手順
A solution of 1-(4-methylphenyl)pyrrole-2-carbonitrile (4.9 g), N-bromosuccinimide (5.5 g) and perbenzoic acid (65 mg) in carbon tetrachloride was heated under reflux in light radiation for 2 hours. After removal of insoluble materials by filtration, the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford a colorless syrup (6.6 g, 93%).
後処理
- temperatureunder reflux in light radiation for 2 hours
- customAfter removal of insoluble materials
- filtrationby filtration
- concentrationthe filtrate was concentrated to dryness
- customThe residue was purified by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-490f5ed6fd034cfc9f921723c0596a31
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05389641
反応ノート
読み込み中…