N-bromobutanimide → 1H-Pyrrole-2-carbonitrile, 1-[4-(bromomethyl)phenyl]-

HRID 274566

反応式

HRID 274566 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][CH:10]=[C:9]2[C:13]#[N:14])=[CH:4][CH:3]=1.[Br:15]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C1C(C(OO)=O)=CC=CC=1>[Br:15][CH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][CH:10]=[C:9]2[C:13]#[N:14])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 27977151-(4-Methylphenyl)pyrrole-2-carbonitrile

生成物 1

HCID 103328611H-Pyrrole-2-carbonitrile, 1-[4-(bromomethyl)phenyl]-収率 94%

試薬・触媒・溶媒 2

HCID 523077Perbenzoic acid触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

A solution of 1-(4-methylphenyl)pyrrole-2-carbonitrile (4.9 g), N-bromosuccinimide (5.5 g) and perbenzoic acid (65 mg) in carbon tetrachloride was heated under reflux in light radiation for 2 hours. After removal of insoluble materials by filtration, the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford a colorless syrup (6.6 g, 93%).

後処理

  1. temperatureunder reflux in light radiation for 2 hours
  2. customAfter removal of insoluble materials
  3. filtrationby filtration
  4. concentrationthe filtrate was concentrated to dryness
  5. customThe residue was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-490f5ed6fd034cfc9f921723c0596a31
出典データセット
uspto-grants-1995_02
特許番号
US05389641

関連ノート

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