1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 274762

反応式

HRID 274762 の反応式
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([OH:14])=[O:13].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([OH:1])=[C:3]([C:12]([OH:14])=[O:13])[CH:4]=1

参加物

4

反応物 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 24408Bromine

生成物 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a suspension of 1-hydroxy-2-naphthoic acid (2.5 g; 13.3 mm) in chloroform (50 ml) was added bromine (0.68 ml) in chloroform (5 ml) dropwise and the reaction stirred at room temperature for one hour. The solvent was removed in vacuo, the solid washed repeatedly with water and collected by filtration and dried to give 4-bromo-1-hydroxy-naphthalene-2-carboxylic acid as a white solid.

後処理

  1. customThe solvent was removed in vacuo
  2. washthe solid washed repeatedly with water
  3. filtrationcollected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-657abbb53a14432ebc0bf161407cc8a6
出典データセット
uspto-grants-1995_02
特許番号
US05389684

関連ノート

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