Sulfuryl chloride → Ethyl 2-chloro-3-oxopentanoate
反応式
S(Cl)([Cl:4])(=O)=O.[O:6]=[C:7]([CH2:14][CH3:15])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(Cl)(Cl)Cl>[Cl:4][CH:8]([C:7](=[O:6])[CH2:14][CH3:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10]参加物
4
実験手順
Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hour and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.
後処理
- additionaddition the mixture
- temperatureheated
- temperatureunder reflux for 0.5 hour
- temperaturecooled
- washAfter washing with water, sodium bicarbonate and water
- dry with materialthe solution was dried (sodium sulphate)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-4bf2e9ed074343889166e28dfcebce1b
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04221802
反応ノート
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