Sulfuryl chloride → Ethyl 2-chloro-3-oxopentanoate

HRID 27489

反応式

HRID 27489 の反応式
S(Cl)([Cl:4])(=O)=O.[O:6]=[C:7]([CH2:14][CH3:15])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(Cl)(Cl)Cl>[Cl:4][CH:8]([C:7](=[O:6])[CH2:14][CH3:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10]

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 78656Ethyl 3-oxovalerate

生成物 1

HCID 12923424Ethyl 2-chloro-3-oxopentanoate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hour and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.

後処理

  1. additionaddition the mixture
  2. temperatureheated
  3. temperatureunder reflux for 0.5 hour
  4. temperaturecooled
  5. washAfter washing with water, sodium bicarbonate and water
  6. dry with materialthe solution was dried (sodium sulphate)
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-4bf2e9ed074343889166e28dfcebce1b
出典データセット
uspto-grants-1980_09
特許番号
US04221802

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