4-(Trifluoromethyl)phenylhydrazine → 2-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazone

HRID 275258

反応式

HRID 275258 の反応式
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=O)=[O:7].[F:22][C:23]([F:33])([F:32])[C:24]1[CH:29]=[CH:28][C:27]([NH:30][NH2:31])=[CH:26][CH:25]=1>CO.C1(C)C=CC(S(O)(=O)=O)=CC=1>[F:22][C:23]([F:32])([F:33])[C:24]1[CH:25]=[CH:26][C:27]([NH:30][N:31]=[C:10]([OH:12])[C:9]2[CH:13]=[CH:14][CH:15]=[N:16][C:8]=2[C:6](=[O:7])[C:5]2[CH:17]=[CH:18][CH:19]=[C:3]([C:2]([F:1])([F:21])[F:20])[CH:4]=2)=[CH:28][CH:29]=1

参加物

5

反応物 2

HCID 1362004-(Trifluoromethyl)phenylhydrazineHCID 200788952-(3-Trifluoromethylbenzoyl)nicotinic acid

生成物 1

HCID 1785195602-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazone収率 80.7%

試薬・触媒・溶媒 2

HCID 6101p-Toluenesulfonic acid触媒HCID 887Methanol溶媒

実験手順

2-(3-Trifluoromethylbenzoyl)nicotinic acid (0.5 g), 4-trifluoromethylphenylhydrazine (0.3 g) and para-toluene sulphonic acid (0.001 g) were stirred in methanol at room temperature for 22 hours. Solvent was evaporated. The residue was triturated in cold toluene then dried to yield the title compound as a beige solid (0.62 g), m.p. 127°-129° C.

後処理

  1. customSolvent was evaporated
  2. customThe residue was triturated in cold toluene
  3. customthen dried

出典と根拠

ORDレコード
ord-0f21748979904a6cb9e4027cefd1fe85
出典データセット
uspto-grants-1995_02
特許番号
US05393730

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