Acetic Acid → 6-methoxymethoxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

HRID 275457

反応式

HRID 275457 の反応式
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]([CH3:17])[C:5]2[O:10][C:9]([CH3:14])([C:11]([OH:13])=[O:12])[CH2:8][CH2:7][C:6]=2[C:15]=1[CH3:16].[CH3:19][O:20][CH2:21]Br.C(O)(=O)C>N1C=CC=CC=1>[CH3:19][O:20][CH2:21][O:1][C:2]1[C:3]([CH3:18])=[C:4]([CH3:17])[C:5]2[O:10][C:9]([CH3:14])([C:11]([OH:13])=[O:12])[CH2:8][CH2:7][C:6]=2[C:15]=1[CH3:16]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 40634TroloxHCID 83093Bromomethyl methyl ether

生成物 1

HCID 200865506-methoxymethoxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

50 grams (0.2 mol) of 6-hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid are dissolved in 150 cm3 of anhydrous pyridine. 16.34 cm3 (0.2 mol) of bromomethyl methyl ether are added dropwise. The mixture is stirred for 2 hours and then the solution is poured onto ice. The mixture is acidified with acetic acid and then extracted with methylene chloride. The organic phase is washed with water and dried over anhydrous sodium sulfate, then the title product is purified by passing through a column of silica gel, eluting with methylene chloride.

後処理

  1. additionthe solution is poured onto ice
  2. extractionextracted with methylene chloride
  3. washThe organic phase is washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customthe title product is purified
  6. washeluting with methylene chloride

出典と根拠

ORDレコード
ord-dffafdcd23b347c09fb6c401bf364e2c
出典データセット
uspto-grants-1995_02
特許番号
US05393775

関連ノート

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