N-bromobutanimide → HCID 178488288、化合物
反応式
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[NH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[Br:16]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Br:16][C:6]1[C:7]2[NH:11][C:10]([C:12]([F:15])([F:13])[F:14])=[N:9][C:8]=2[C:3]([O:2][CH3:1])=[CH:4][CH:5]=1参加物
4
実験手順
A solution of 7-methoxy-2-trifluoromethylbenzimidazole (50 g) in chloroform (100 ml) was cooled to 0° C., and N-bromosuccinimide (4.5 g) added. The mixture was stirred for 2 h. It was then washed with 5% aqueous sodium metabisulphite (50 ml), dried over magnesium sulphate, evaporated in vacuo and purified by flash chromatography eluting with 25% ethyl acetate in hexane to yield the title compound as a white solid (1.0 g).
後処理
- washIt was then washed with 5% aqueous sodium metabisulphite (50 ml)
- dry with materialdried over magnesium sulphate
- customevaporated in vacuo
- custompurified by flash chromatography
- washeluting with 25% ethyl acetate in hexane
出典と根拠
- ORDレコード
- ord-63841f4d1017428fb7f908bd82660fbe
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06353010B1
反応ノート
読み込み中…