Hydrochloric Acid → 6-Methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([CH3:13])=[N:8][CH2:7][CH2:6]2.[BH4-].[Na+].Cl.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]([CH3:13])[NH:8][CH2:7][CH2:6]2参加物
6
実験手順
6-methoxy-1-methyl-3,4-dihydroisoquinoline (54.0 g, 0.31 mmol) was added to a suspension of sodium borohydride(5.8 g, 138 mmol) in ethanol. The mixture solution was stirred for 1 hour at a room temperature, cooled to below 5° C., acidified with diluted hydrochloric acid, adjusted to alkali with sodium hydroxide solution, and then extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under a reduced pressure to give 45.4 g of the titled compound.
後処理
- temperaturecooled to below 5° C.
- extractionextracted with ethyl acetate
- dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
- concentrationconcentrated under a reduced pressure
出典と根拠
- ORDレコード
- ord-0d7c703eacdf49228d4185d8be026748
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06352993B1
反応ノート
読み込み中…