Thionyl Chloride → 1-(Chloromethyl)-4-phenoxybenzene

HRID 276076

反応式

HRID 276076 の反応式
S(Cl)([Cl:3])=O.[O:5]([C:12]1[CH:19]=[CH:18][C:15]([CH2:16]O)=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[O:5]([C:12]1[CH:19]=[CH:18][C:15]([CH2:16][Cl:3])=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 826195(4-Phenoxyphenyl)methanol

生成物 1

HCID 5209941-(Chloromethyl)-4-phenoxybenzene収率 97.2%

反応条件

温度
80 °C

実験手順

Thionyl chloride (13.34 g) was added to 4.06 g of 4-phenoxybenzyl alcohol, and the mixture was stirred at 80° C. for 3.5 hours. After the completion of the concentration, the reaction mixture was extracted with ethyl acetate and with water. The organic layer was concentrated to give 4.31 g of 4-phenoxybenzyl chloride.

後処理

  1. concentrationAfter the completion of the concentration
  2. extractionthe reaction mixture was extracted with ethyl acetate and with water
  3. concentrationThe organic layer was concentrated

出典と根拠

ORDレコード
ord-e48630886bf3471b8d19ba088efbd56b
出典データセット
uspto-grants-2002_03
特許番号
US06352985B1

関連ノート

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