Bromine → HCID 20287115、化合物

HRID 27622

反応式

HRID 27622 の反応式
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:14][CH3:15])=[C:8]([CH:13]=1)[C:9]([O:11][CH3:12])=[O:10])(=[O:3])[CH3:2].[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH2:2][C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:14][CH3:15])=[C:8]([CH:13]=1)[C:9]([O:11][CH3:12])=[O:10])=[O:3]

参加物

4

反応物 2

HCID 24408BromineHCID 606426Methyl 5-acetyl-2-methoxybenzoate

生成物 1

HCID 20287115HCID 20287115、化合物収率 75.4%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a solution of 52.0 g (0.25 mole) of this ketone in 400 ml of chloroform is added a solution of 40.0 g (0.25 mole) of bromine in 200 ml of chloroform at such a rate as reaction mixture decolorizes (50 minutes after a 25 minute initiation period). Solvent is evaporated and the residue recrystallized from methanol to give 54.1 g (75%) of methyl 5-(2-bromoacetyl)-2-methoxybenzoate, m.p. 149°-153° C. A second crop of 10.4 g is obtained from the mother liquor.

後処理

  1. customas reaction mixture
  2. custom50 minutes
  3. customafter a 25 minute
  4. customSolvent is evaporated
  5. customthe residue recrystallized from methanol

出典と根拠

ORDレコード
ord-c36183a7d8af4e76bb9decf1a4cd7b2b
出典データセット
uspto-grants-1980_09
特許番号
US04221808

関連ノート

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