Thionyl Chloride → 1-(chloromethyl)-1-(cyclohexylamino)cyclopentane HCl salt
反応式
[CH:1]1([NH:7][C:8]2([CH2:13]O)[CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O=S(Cl)[Cl:17]>Cl>[ClH:17].[Cl:17][CH2:13][C:8]1([NH:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH2:12][CH2:11][CH2:10][CH2:9]1参加物
4
反応条件
- 温度
- 70 °C
実験手順
A 4M HCl solution (p-dioxane, 40 mL) containing 1-(cyclohexylamino)-1-(hydroxymethyl)cyclopentane (Method B4a; 1.9 g, 9.6 mmol) and SOCl2 (0.84 mL, 11.5 mmol) was heated to 70° C. for 18 h. The resulting mixture was cooled to room temp. and concentrated under reduced pressure to yield crude 1-(chloromethyl)-1-(cyclohexylamino)cyclopentane HCl salt (2.84 g), which was used in the next step without firer purification.
後処理
- temperatureThe resulting mixture was cooled to room temp.
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-2c95e3be24164d069c9b63100bdf0900
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06353006B1
反応ノート
読み込み中…