Ethanolamine → 2-(4-Chloro-benzylamino)-ethanol

HRID 276411

反応式

HRID 276411 の反応式
[OH:1][CH2:2][CH2:3][NH2:4].[Cl:5][C:6]1[CH:13]=[CH:12][C:9]([CH2:10]Br)=[CH:8][CH:7]=1>>[Cl:5][C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH:4][CH2:3][CH2:2][OH:1])=[CH:8][CH:7]=1

参加物

3

反応物 2

HCID 700EthanolamineHCID 693291-(Bromomethyl)-4-chlorobenzene

生成物 1

HCID 4244522-(4-Chloro-benzylamino)-ethanol

実験手順

2-Hydroxyethylamine was reacted with 4-chlorobenzyl bromide according to Method B2a to give N-(4-chlorobenzyl)-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-(4-chlorobenzyl)-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 4-cyano-2-ethylphenyl isothiocyanate to give 2-(4-cyano-2-ethylphenylimino)-3-(4-chlorobenzyl)-1,3-thiazolidine.

出典と根拠

ORDレコード
ord-973ec244a89847bc9204433344792d09
出典データセット
uspto-grants-2002_03
特許番号
US06353006B1

関連ノート

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