Ethanolamine → 1-Aminocyclopentanemethanol
反応式
C([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])CC.IC1C=[CH:17][C:15]([NH2:16])=[C:14]([CH2:19][CH2:20][CH3:21])C=1.NC1C=CC=CC=1.IC1C=CC(N=C=S)=C(CCC)C=1.[OH:42]CCN.O=S(Cl)[Cl:48]>>[NH2:6][C:5]1([CH2:4][OH:42])[CH2:7][CH2:8][CH2:9][CH2:10]1.[ClH:48].[NH2:16][C:15]1([CH2:17][Cl:48])[CH2:14][CH2:19][CH2:20][CH2:21]1参加物
実験手順
2-n-Propylaniline was converted to 4-iodo-2-n-propylaniline according to Method A5a. The aniline was converted to 4-iodo-2-n-propylphenyl isothiocyanate according to Method A2b. 1-Amino-1-(hydroxymethyl)cyclopentane was synthesized as described in Method B1c. The 2-hydroxyethylamine was reacted with SOCl2 according to Method B7a to give 1-amino-1-(chloromethyl)cyclopentane HCl salt. The 2-chloroethylamine was reacted with 4-iodo-2-n-propylphenyl isothiocyanate according to Method C1a to give 2-(4-iodo-2-n-propylphenylimino)-1-thia-3-azaspiro[4.4]nonane. The thiazolidine was reacted with cyclopentyl bromide according to Method D2b to give 3-cyclopentyl-2-(4-iodo-2-n-propylphenylimino)-1-thia-3-azaspiro[4.4]nonane. The phenyl iodide was reacted with CuCN according to Method D7a to afford 3-cyclopentyl-2-(4-cyano-2-n-propylphenylimino)-1-thia-3-azaspiro[4.4]nonane.
出典と根拠
- ORDレコード
- ord-19a83d802be04ced89d022ac8783c61c
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06353006B1
反応ノート
読み込み中…