Water → 2-(4-Benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide

HRID 277567

反応式

HRID 277567 の反応式
[CH3:1][CH:2]([CH3:15])[C:3](=[O:14])[CH2:4][C:5]([NH:7]C1C=CC=CC=1)=[O:6].[CH2:16]([O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.N1C=CC=CC=1.O>C1(C)C(C)=CC=CC=1>[CH2:16]([O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=[C:4]([C:3](=[O:14])[CH:2]([CH3:15])[CH3:1])[C:5]([NH2:7])=[O:6])=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 78109Benzaldehyde, 4-(phenylmethoxy)-HCID 102198994-methyl-3-oxo-N-phenylpentanamide

生成物 1

HCID 540483912-(4-Benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

Step A—A solution of 4-methyl-N-phenyl-3-oxopentanamide, 12, (5 mmol), 4-benzyloxybenzaldehyde (5 mmol) and pyridine (1 mL) in xylene (100 mL) is heated at reflux, with azeotropic removal of water. The progress of the reaction is monitored by tlc. When the reaction is complete, the solvent is removed under reduced pressure, and the residue is chromatographed to afford 2-(4-benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide, 13, (R=4-benzyloxy).

後処理

  1. customthe solvent is removed under reduced pressure
  2. customthe residue is chromatographed

出典と根拠

ORDレコード
ord-dd175ec9fb224853972661988935f5aa
出典データセット
uspto-grants-2002_03
特許番号
US06355810B1

関連ノート

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