Triphenylphosphine → 4-Bromo-2-(bromomethyl)-1-fluorobenzene
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[CH2:7]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Br:30]N1C(=O)CCC1=O>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[CH2:7][Br:30]参加物
5
実験手順
To a solution of 5-bromo-2-fluoro-benzyl alcohol (3.10 g, 15.1 mmol) in 30 mL of THF at 10° C. is added triphenyl phosphine (4.10 g, 15.6 mmol) followed by N-bromosuccinimide (2.67 g, 15.0 mmol). The ice bath is removed and the resulting solution is stirred for 20 min at room temperature. The crude product is purified by column chromatography eluting with 5% EtOAc/hexanes to give the title compound (3.90 g, 14.5 mmol).
後処理
- customThe ice bath is removed
- customThe crude product is purified by column chromatography
- washeluting with 5% EtOAc/hexanes
出典と根拠
- ORDレコード
- ord-01265d1ee5214b12aaf7fb783abeb10c
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731315
反応ノート
読み込み中…