N-bromobutanimide → 3-Chloro-6-(3,5-dimethyl-4-bromo-1-pyrazolyl)-pyridazine

HRID 27890

反応式

HRID 27890 の反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[CH:11][C:10]([CH3:14])=[N:9]2)=[CH:6][CH:7]=1.[Br:15]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([Br:15])[C:10]([CH3:14])=[N:9]2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 3210733-Chloro-6-(3,5-dimethylpyrazol-1-yl)pyridazine

生成物 1

HCID 125628443-Chloro-6-(3,5-dimethyl-4-bromo-1-pyrazolyl)-pyridazine

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of 2.09 g (0.01 moles) of 3-chloro-6-(3,5-dimethyl-1-pyrazolyl)-pyridazine, 21 ml of carbon tetrachloride and 1.96 g (0.011 moles) of N-bromosuccinimide is boiled under stirring for 3 hours. After cooling the precipitate is filtered, washed with carbon tetrachloride and recrystallized from ethanol. Yield: 1.44 g (50.5%); m.p.: 143°-145° C.

後処理

  1. temperatureAfter cooling the precipitate
  2. filtrationis filtered
  3. washwashed with carbon tetrachloride
  4. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-b46bc50829b44cafb7981c0fd1a27fe7
出典データセット
uspto-grants-1980_09
特許番号
US04224325

関連ノート

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