Dimethylformamide → 4-Bromo-2,2-diphenylbutyric chloride

HRID 279073

反応式

HRID 279073 の反応式
[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](O)=[O:6].S(Cl)([Cl:22])=O.CN(C)C=O>C(Cl)(Cl)Cl>[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5]([Cl:22])=[O:6]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 27569594-Bromo-2,2-diphenylbutyric acid

生成物 1

HCID 222500664-Bromo-2,2-diphenylbutyric chloride収率 94.7%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

4-Bromo-2,2-diphenylbutyric acid 23 g (72 mmol) was suspended in 150 mL of chloroform. At room temperature, 20 mL (270 mmol) of thionyl chloride was added dropwise to the resulting suspension. After addition of 0.2 mL of dimethylformamide, the resulting mixture was heated under reflux for 4 hours. After completion of the reaction, the solvent was concentrated under reduced pressure, whereby 23 g (yield: 94.7%) of 4-bromo-2,2-diphenylbutyric chloride was obtained.

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 4 hours
  3. customAfter completion of the reaction
  4. concentrationthe solvent was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-18aefa498618404db98a73d8d2df4637
出典データセット
uspto-grants-2002_03
特許番号
US06362203B1

関連ノート

読み込み中…