Sodium Hydroxide → 2-[4-(4-Carboxymethylphenyl)-3-cyclohexen-1-yl]propyl 2-propanesulfonamide

HRID 279359ノート

反応式

HRID 279359 の反応式
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH2:15][CH2:14][CH:13]([CH:16]([CH3:25])[CH2:17][CH2:18][CH:19]([S:21]([NH2:24])(=[O:23])=[O:22])[CH3:20])[CH2:12][CH:11]=2)=[CH:6][CH:5]=1)#N.[OH-:26].[Na+].S(=O)(=O)(O)[O-:29].[Na+]>O1CCOCC1>[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH2:15][CH2:14][CH:13]([CH:16]([CH3:25])[CH2:17][CH2:18][CH:19]([S:21]([NH2:24])(=[O:23])=[O:22])[CH3:20])[CH2:12][CH:11]=2)=[CH:6][CH:5]=1)([OH:29])=[O:26]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 516919Sodium BisulfateHCID 867579052-[4-(4-Cyanomethylphenyl)-3-cyclohexen-1-yl]propyl 2-propanesulfonamide

生成物 1

HCID 867562312-[4-(4-Carboxymethylphenyl)-3-cyclohexen-1-yl]propyl 2-propanesulfonamide

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
100 °C

実験手順

To a solution of N-[2-[4-(4-cyanomethylphenyl)-3-cyclohexen-1-yl]propyl 2-propanesulfonamide (see Example 15) in dioxane is added 5 N sodium hydroxide. The mixture is heated to 100° C. for 24 hr. The mixture is then cooled, and acidified with 10% aqueous sodium bisulfate. The mixture is extracted three times with ethyl acetate and the combined organic extracts are dried, filtered and concentrated in vacuo to afford the title compound.

後処理

  1. temperatureThe mixture is then cooled
  2. extractionThe mixture is extracted three times with ethyl acetate
  3. customthe combined organic extracts are dried
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-c492a67587874836829d7f95f2992b0d
出典データセット
uspto-grants-2002_03
特許番号
US06362230B1

反応ノート

読み込み中…