Pyridine → N-Methoxy-N,4-dimethyloxazole-5-carboxamide
反応式
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[C:7](Cl)=[O:8].Cl.[CH3:11][NH:12][O:13][CH3:14].N1C=CC=CC=1.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[CH3:14][O:13][N:12]([CH3:11])[C:7]([C:6]1[O:5][CH:4]=[N:3][C:2]=1[CH3:1])=[O:8]参加物
6
実験手順
4-Methyl-5-oxazolecarbonyl chloride (15 g) and N,O-dimethylhydroxylamine hydrochloride (11 g) in dry chloroform (100 ml) were cooled to 0° C. and dry pyridine (28.5 g) was added. The mixture was allowed to warm to room temperature. After 30 minutes aqueous sodium hydrogen carbonate was added and the organic layer separated. The aqueous layer was extracted with dichloromethane. The combined organic layers were washed, dried and evaporated. The residue was purified by flash chromatography to yield the title compound as a white solid. M.p. 59°-60° C.
後処理
- customthe organic layer separated
- extractionThe aqueous layer was extracted with dichloromethane
- washThe combined organic layers were washed
- customdried
- customevaporated
- customThe residue was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-b9c8478b753b4132a133ace38f7e208b
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731335
反応ノート
読み込み中…