Methyl chloroformate → 4-Fluoro-2-methylphenyl Methoxyformate

HRID 279520

反応式

HRID 279520 の反応式
Cl[C:2]([O:4][CH3:5])=[O:3].[F:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH3:14])[CH:8]=1>[OH-].[Na+]>[C:2](=[O:3])([O:4][CH3:5])[O:13][C:10]1[CH:11]=[CH:12][C:7]([F:6])=[CH:8][C:9]=1[CH3:14]

参加物

4

反応物 2

HCID 6586Methyl chloroformateHCID 1362954-Fluoro-2-methylphenol

生成物 1

HCID 106790444-Fluoro-2-methylphenyl Methoxyformate収率 78.4%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

Methyl chloroformate (6.8 ml, 88 mmol) was added over 30 minutes to a solution of 4-fluoro-2-methylphenol (10 g, 79 mmol) in 6% aqueous sodium hydroxide solution at 0° C. The mixture was stirred for 2 hours, then extracted with ethyl acetate (100 ml). The ethyl acetate extract was washed with water (100 ml) and dried (MgSO4) and the solvent removed by evaporation to give 4-fluoro-2-methylphenyl methyl carbonate (11.4 g, 78%) as an oil.

後処理

  1. extractionextracted with ethyl acetate (100 ml)
  2. extractionThe ethyl acetate extract
  3. washwas washed with water (100 ml)
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed by evaporation

出典と根拠

ORDレコード
ord-4ff12640a73946dbb98797cbaf6b00e7
出典データセット
uspto-grants-2002_03
特許番号
US06362336B1

関連ノート

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