Sodium Hydroxide → 5-Amino-4-fluoro-2-methylphenol

HRID 279522

反応式

HRID 279522 の反応式
[F:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([OH:11])=[C:4]([CH3:12])[CH:3]=1.[OH-].[Na+]>O.[Fe].S([O-])([O-])(=O)=O.[Fe+2]>[F:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([OH:11])=[CH:6][C:7]=1[NH2:8]

参加物

6

反応物 2

HCID 14798Sodium HydroxideHCID 108210594-Fluoro-2-methyl-5-nitrophenol

生成物 1

HCID 101540985-Amino-4-fluoro-2-methylphenol収率 47%

試薬・触媒・溶媒 3

HCID 23925Iron触媒HCID 24393Ferrous Sulfate触媒HCID 962Water溶媒

実験手順

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was refluxed for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

後処理

  1. temperaturewas refluxed for 4 hours
  2. temperatureto cool
  3. extractionextracted with ethyl acetate (100 ml)
  4. extractionThe ethyl acetate extract
  5. dry with materialwas dried (MgSO4)
  6. customthe solvent removed by evaporation

出典と根拠

ORDレコード
ord-a3442004905d4deb843926e2b8dcbb1a
出典データセット
uspto-grants-2002_03
特許番号
US06362336B1

関連ノート

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