Thionyl Chloride → 2-(Chloromethyl)-1-methylbenzimidazole
反応式
O[CH2:2][C:3]1[N:7]([CH3:8])[C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[N:4]=1.S(Cl)([Cl:15])=O>>[Cl:15][CH2:2][C:3]1[N:7]([CH3:8])[C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[N:4]=1参加物
3
実験手順
A solution of 2-hydroxymethyl-1-methylbenzimidazole (1.1 g, 6.7 mmol) in thionyl chloride (10 ml) was stirred at ambient temperature for 15 minutes and then heated at reflux for 15 minutes. The volatiles were removed by evaporation and the residue purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 2-chloromethyl-1-methylbenzimidazole (506 mg, 36%).
後処理
- temperatureheated
- temperatureat reflux for 15 minutes
- customThe volatiles were removed by evaporation
- customthe residue purified by column chromatography
- washeluting with methylene chloride/methanol (95/5)
出典と根拠
- ORDレコード
- ord-d8c3115e42f34c5791ca6054fb4ab195
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06362336B1
反応ノート
読み込み中…