Propionic Acid → 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone

HRID 2796

反応式

HRID 2796 の反応式
Cl[CH:2]([C:6](=[O:8])[CH3:7])[C:3](=O)[CH3:4].[C:9]([NH2:13])(=[O:12])[CH2:10][CH3:11].C(O)(=O)CC.[OH-].[Na+]>>[C:6]([C:2]1[O:12][C:9]([CH2:10][CH3:11])=[N:13][C:3]=1[CH3:4])(=[O:8])[CH3:7]

参加物

5

反応物 4

HCID 1032Propionic AcidHCID 6578PropionamideHCID 14798Sodium HydroxideHCID 743283-Chloro-2,4-pentanedione

生成物 1

HCID 189363281-(2-Ethyl-4-methyloxazol-5-yl)ethanone

実験手順

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.

後処理

  1. extractionextracted with dichloromethane
  2. washThe combined extracts were washed with brine
  3. customdried
  4. customthe solvent removed
  5. customto leave a brown oil which
  6. distillationwas purified by vacuum distillation, b.p. 70° C. at 2 mbar

出典と根拠

ORDレコード
ord-eb5bfefcbfd94ea0be77c604cb53b9bd
出典データセット
uspto-grants-1998_03
特許番号
US05731335

関連ノート

読み込み中…