8-Hydroxyquinoline → (3S-trans)-2-Oxo-3-[[(phenylmethoxy)carbonyl]-amino]-4-methyl-1-azetidinesulfonic acid, 8-hydroxyquinolinium salt

(3S-trans)-2-Oxo-3-[[(phenylmethoxy)carbonyl]amino]-4-methyl-1-azetidinesulfonic acid, tetrabutylammonium salt (500 mg, 0.9 mmol) was dissolved in a mixture of water and acetonitrile. The solution was passed through an AGMP-50 ion-exchange resin column (H⊕ form, 7 ml, 1.7 meq/ml) eluting with water. The eluate was run into a flask containing 8-hydroxyquinoline (131 mg, 0.9 mmol). Acetonitrile was removed from the resulting solution under reduced pressure at <35° C. and the remaining aqueous solution was lyophilized yielding a solid. Trituration with ether and drying in vacuo afforded the desired product as a yellow powder (398 mg), melting point 61°-68° C.

1. washeluting with water
2. customThe eluate was run into a flask
3. customAcetonitrile was removed from the resulting solution under reduced pressure at <35° C.
4. customthe remaining aqueous solution was lyophilized yielding a solid
5. dry with materialTrituration with ether and drying in vacuo

ORDレコード

ord-bd9e96b6c99a4a46a76c1c6dcacb3790

出典データセット

uspto-grants-1986_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04587051