2,3-Dihydro-2,5-dimethyl-4-chloro-7-nitrobenzofuran → 7-Amino-2,3-dihydro-2,5-dimethyl-4-chlorobenzofuran

HRID 279897ノート

反応式

HRID 279897 の反応式
[CH3:1][CH:2]1[CH2:6][C:5]2[C:7]([Cl:15])=[C:8]([CH3:14])[CH:9]=[C:10]([N+:11]([O-])=O)[C:4]=2[O:3]1.[H][H]>C1COCC1.[Pd]>[NH2:11][C:10]1[C:4]2[O:3][CH:2]([CH3:1])[CH2:6][C:5]=2[C:7]([Cl:15])=[C:8]([CH3:14])[CH:9]=1

参加物

5

反応物 2

HCID 135756772,3-Dihydro-2,5-dimethyl-4-chloro-7-nitrobenzofuranHCID 178418361HCID 178418361、化合物

生成物 1

HCID 136308847-Amino-2,3-dihydro-2,5-dimethyl-4-chlorobenzofuran

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

51.0 g of 3C was dissolved in 600 ml of THF. The solution was divided in half, and each half was hydrogenated (40-50 psig hydrogen pressure) in the presence of 1 g of palladium-on-charcoal catalyst. The final combined reaction mixtures were filtered, the filtrates were combined, dried (MgSO4) and evaporated to dryness, to give 7-amino-2,3-dihydro-2,5-dimethyl-4-chlorobenzofuran (3D).

後処理

  1. customreaction mixtures
  2. filtrationwere filtered
  3. dry with materialdried (MgSO4)
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-0304a65309b845ad8c043a8dab4a862a
出典データセット
uspto-grants-1986_05
特許番号
US04587259

反応ノート

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