Phenylurea → p-Nitrophenyl phenylcarbamoylcarbamate

HRID 27992

反応式

HRID 27992 の反応式
[C:1]1([NH:7][C:8]([NH2:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:13]>C1COCC1>[C:1]1([NH:7][C:8]([NH:10][C:12](=[O:13])[O:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 6145PhenylureaHCID 821294-Nitrophenyl chloroformate

生成物 1

HCID 13097706p-Nitrophenyl phenylcarbamoylcarbamate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 6.8 g. of phenylurea in 50 ml. of dry THF maintained at 0° C. under nitrogen were added 5.05 g. of p-nitrophenyl chloroformate. The reaction mixture was allowed to warm to room temperture and was stirred for about 18 hours. The mixture was evaporated to dryness and the residue dissolved in ethyl acetate. The solution was washed twice with water, twice with brine, and was filtered through sodium sulfate. The filtrate was evaporated to dryness to yield 4.9 g. of the product as a white product.

後処理

  1. additionwere added 5.05 g
  2. temperatureto warm to room temperture
  3. customThe mixture was evaporated to dryness
  4. dissolutionthe residue dissolved in ethyl acetate
  5. washThe solution was washed twice with water, twice with brine
  6. filtrationwas filtered through sodium sulfate
  7. customThe filtrate was evaporated to dryness
  8. customto yield 4.9 g

出典と根拠

ORDレコード
ord-f7c73e145846469f815f3d2c37bfe350
出典データセット
uspto-grants-1980_09
特許番号
US04224442

関連ノート

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