Thionyl Chloride → 2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester
反応式
[CH3:1][O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[S:10]([OH:13])(=O)=[O:11])=[O:4].S(Cl)([Cl:16])=O>>[CH3:1][O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[S:10]([Cl:16])(=[O:13])=[O:11])=[O:4]参加物
3
実験手順
7.4 G. of crude 3-sulfothiophene-2-carboxylic acid methyl ester are dissolved in 50 ml. of thionyl chloride and boiled to reflux for 16 hours. The mixture is then evaporated to dryness in vacuo and the remaining bright-yellow oil is brought to crystallization with petroleum ether. There is obtained 3-chlorosulfonylthiophene-2-carboxylic acid methyl ester.
後処理
- temperatureto reflux for 16 hours
- customThe mixture is then evaporated to dryness in vacuo
- customthe remaining bright-yellow oil is brought to crystallization with petroleum ether
出典と根拠
- ORDレコード
- ord-f36a817170be4689979b6134143063af
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04224445
反応ノート
読み込み中…