Thionyl Chloride → 2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester

HRID 28000

反応式

HRID 28000 の反応式
[CH3:1][O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[S:10]([OH:13])(=O)=[O:11])=[O:4].S(Cl)([Cl:16])=O>>[CH3:1][O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[S:10]([Cl:16])(=[O:13])=[O:11])=[O:4]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 214315792-(Methoxycarbonyl)thiophene-3-sulfonic acid

生成物 1

HCID 27367332-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester

実験手順

7.4 G. of crude 3-sulfothiophene-2-carboxylic acid methyl ester are dissolved in 50 ml. of thionyl chloride and boiled to reflux for 16 hours. The mixture is then evaporated to dryness in vacuo and the remaining bright-yellow oil is brought to crystallization with petroleum ether. There is obtained 3-chlorosulfonylthiophene-2-carboxylic acid methyl ester.

後処理

  1. temperatureto reflux for 16 hours
  2. customThe mixture is then evaporated to dryness in vacuo
  3. customthe remaining bright-yellow oil is brought to crystallization with petroleum ether

出典と根拠

ORDレコード
ord-f36a817170be4689979b6134143063af
出典データセット
uspto-grants-1980_09
特許番号
US04224445

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