Methyl iodide → 4-Bromo-1,3,5-trimethylpyrazole
反応式
[Br:1][C:2]1[C:3]([CH3:8])=[N:4][NH:5][C:6]=1[CH3:7].[H-].[Na+].[H][H].IC.[C:15](=O)([O-])O.[Na+]>CN(C)C=O>[Br:1][C:2]1[C:3]([CH3:8])=[N:4][N:5]([CH3:15])[C:6]=1[CH3:7]参加物
7
実験手順
4-Bromo-3,5-dimethylpyrazole (10 g) in dry dimethylformamide (50 ml) was added to a stirred suspension of sodium hydride (1.8 g) in dry dimethylformamide at 0° C. When the evolution of hydrogen was complete, iodomethane (8.9 g) was added dropwise. The mixture was allowed to warm to room temperature and after 30 minutes saturated aqueous sodium hydrogen carbonate (5 ml) was added. Following evaporation under high vacuum, the residue was purified by column chromatography to give the title compound.
後処理
- additionwas added
- customevaporation under high vacuum
- customthe residue was purified by column chromatography
出典と根拠
- ORDレコード
- ord-ac7f5eb35ef547d1a557dea38319f19e
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731335
反応ノート
読み込み中…