4-Nitrophenol → Diethyl[2-(4-nitrophenoxy)ethyl]amine
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[H-].[Na+].[CH2:13]([N:15]([CH2:19][CH3:20])[CH2:16][CH2:17]Cl)[CH3:14]>CN(C=O)C>[CH2:13]([N:15]([CH2:19][CH3:20])[CH2:16][CH2:17][O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)[CH3:14]参加物
5
実験手順
To a cold solution of 41.8 g of 4-nitrophenol in 250 ml of DMF was added 16.0 g of a 57% dispersion of sodium hydride in mineral oil, followed by 46.0 g of 2-diethylaminoethyl chloride. After 20 hours, the mixture was filtered, freed of solvent by evaporation under reduced pressure, the residue dissolved in ether and washed with water. Extraction with 2N hydrochloric acid and basification of the extract gave N,N-diethyl-2-(4-nitrophenoxy)ethanamine.
後処理
- filtrationthe mixture was filtered
- customfreed of solvent by evaporation under reduced pressure
- dissolutionthe residue dissolved in ether
- washwashed with water
- extractionExtraction with 2N hydrochloric acid and basification of the extract
出典と根拠
- ORDレコード
- ord-8642a758cc744568a9c3812c649ac4ca
- 出典データセット
- uspto-grants-1986_05
- 特許番号
- US04588730
反応ノート
読み込み中…