4-Nitrophenol → Diethyl[2-(4-nitrophenoxy)ethyl]amine

HRID 280256

反応式

HRID 280256 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[H-].[Na+].[CH2:13]([N:15]([CH2:19][CH3:20])[CH2:16][CH2:17]Cl)[CH3:14]>CN(C=O)C>[CH2:13]([N:15]([CH2:19][CH3:20])[CH2:16][CH2:17][O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)[CH3:14]

参加物

5

反応物 3

HCID 9804-NitrophenolHCID 13364Diethylaminoethyl chlorideHCID 24758Sodium hydride

生成物 1

HCID 88294Diethyl[2-(4-nitrophenoxy)ethyl]amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a cold solution of 41.8 g of 4-nitrophenol in 250 ml of DMF was added 16.0 g of a 57% dispersion of sodium hydride in mineral oil, followed by 46.0 g of 2-diethylaminoethyl chloride. After 20 hours, the mixture was filtered, freed of solvent by evaporation under reduced pressure, the residue dissolved in ether and washed with water. Extraction with 2N hydrochloric acid and basification of the extract gave N,N-diethyl-2-(4-nitrophenoxy)ethanamine.

後処理

  1. filtrationthe mixture was filtered
  2. customfreed of solvent by evaporation under reduced pressure
  3. dissolutionthe residue dissolved in ether
  4. washwashed with water
  5. extractionExtraction with 2N hydrochloric acid and basification of the extract

出典と根拠

ORDレコード
ord-8642a758cc744568a9c3812c649ac4ca
出典データセット
uspto-grants-1986_05
特許番号
US04588730

関連ノート

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