Potassium Iodide → N-(2,6-dimethylphenyl)-N-(1-ethyl-4-piperidinyl)benzeneacetamide

HRID 28149ノート

反応式

HRID 28149 の反応式
I[CH2:2][CH3:3].[CH3:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:6]=1[N:12]([CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[C:13](=[O:21])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>C1C=CC=CC=1>[CH3:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:6]=1[N:12]([CH:22]1[CH2:27][CH2:26][N:25]([CH2:2][CH3:3])[CH2:24][CH2:23]1)[C:13](=[O:21])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 6340IodoethaneHCID 10340Sodium CarbonateHCID 23339027N-(2,6-dimethylphenyl)-N-(4-piperidinyl)benzeneacetamide

生成物 1

HCID 23339023N-(2,6-dimethylphenyl)-N-(1-ethyl-4-piperidinyl)benzeneacetamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 4 parts of iodoethane, 5 parts of N-(2,6-dimethylphenyl)-N-(4-piperidinyl)benzeneacetamide, 5 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of benzene is stirred and refluxed for 23 hours. The reaction mixture is filtered hot and the filtrate is evaporated in vacuo. The solid residue is crystallized from 1,1'-oxybisethane, yielding 2 parts of N-(2,6-dimethylphenyl)-N-(1-ethyl-4-piperidinyl)-benzeneacetamide; mp. 86.5° C.

後処理

  1. temperaturerefluxed for 23 hours
  2. filtrationThe reaction mixture is filtered hot
  3. customthe filtrate is evaporated in vacuo
  4. customThe solid residue is crystallized from 1,1'-oxybisethane

出典と根拠

ORDレコード
ord-aab89c7a23234d3ba95280b803fe0545
出典データセット
uspto-grants-1980_09
特許番号
US04225606

反応ノート

読み込み中…