Pyrrolidine → 1-(1,3-Dioxobutyl)pyrrolidine
反応式
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[O:6]=[C:2]([CH3:1])[CH2:3][C:4]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:5]参加物
4
実験手順
9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.
後処理
- customas described in preparation 7
- customThe solvent was removed in vacuo
- customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)
出典と根拠
- ORDレコード
- ord-fc50405695d1443a80eda06a3dd99d45
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731322
反応ノート
読み込み中…