Pyrrolidine → 1-(1,3-Dioxobutyl)pyrrolidine

HRID 2849

反応式

HRID 2849 の反応式
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[O:6]=[C:2]([CH3:1])[CH2:3][C:4]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:5]

参加物

4

反応物 2

HCID 31268PyrrolidineHCID 87118046Diketene acetone

生成物 1

HCID 1007221-(1,3-Dioxobutyl)pyrrolidine収率 97.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.

後処理

  1. customas described in preparation 7
  2. customThe solvent was removed in vacuo
  3. customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)

出典と根拠

ORDレコード
ord-fc50405695d1443a80eda06a3dd99d45
出典データセット
uspto-grants-1998_03
特許番号
US05731322

関連ノート

読み込み中…