Sodium Hydroxide → HCID 178418387、化合物

HRID 2852

反応式

HRID 2852 の反応式
[CH3:1][N:2]([CH3:9])[C:3](=[O:8])[CH2:4][C:5](=[O:7])[CH3:6].[OH-].[Na+].[Cl-].[C:13]1([N+:19]#[N:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>O>[CH3:1][N:2]([CH3:9])[C:3](=[O:8])[C:4](=[N:20][NH:19][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:5](=[O:7])[CH3:6]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 16278DimethylacetoacetamideHCID 60992Benzenediazonium chloride

生成物 1

HCID 178418387HCID 178418387、化合物収率 42.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4.5 g (0.035 mol) of N,N-dimethyl-3-oxobutyramide, a solution of 4.9 g (0.122 mol) of NaOH in 45 ml of water and 0.037 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 0%→100%) obtaining 3.5 g of the title compound which was used as such in the subsequent step. M.p.=131°-133° C.

後処理

  1. customas described in preparation 8
  2. customThe crude reaction mixture
  3. customwas purified by chromatography on silica gel (hexane/Et2O 0%→100%)

出典と根拠

ORDレコード
ord-b070703fd73b4d8680fe6f71c91c67d7
出典データセット
uspto-grants-1998_03
特許番号
US05731322

関連ノート

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