p-Toluidine → 6-Chloro-n4-(4-methylphenyl)pyrimidine-2,4-diamine

HRID 28527

反応式

HRID 28527 の反応式
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH2:9])[N:3]=1.[CH3:10][C:11]1[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=1.C(N(CC)C(C)C)(C)C>C(O)C>[Cl:8][C:6]1[N:5]=[C:4]([NH2:9])[N:3]=[C:2]([NH:17][C:14]2[CH:15]=[CH:16][C:11]([CH3:10])=[CH:12][CH:13]=2)[CH:7]=1

参加物

5

反応物 3

HCID 7813p-ToluidineHCID 655222-Amino-4,6-dichloropyrimidineHCID 81531Diisopropylethylamine

生成物 1

HCID 2387486-Chloro-n4-(4-methylphenyl)pyrimidine-2,4-diamine収率 60%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4,6-dichloro-pyrimidin-2-yl-amine (3.3 g, 20 mmol), p-tolylamine (3.4 g, 32 mmol) and N,N-diisopropylethylamine (12 ml) in ethanol (150 ml) was heated under reflux for 40 hours. After cooling to room temperature, filtration provided 6-chloro-N*4*-p-tolyl-pyrimidine-2,4-diamine (2.8 g, 60% yield) as a white solid.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 40 hours
  3. filtrationfiltration

出典と根拠

ORDレコード
ord-4b58f671d02747c482395d81bde4e44d
出典データセット
uspto-grants-2008_09
特許番号
US07419984B2

関連ノート

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