Sodium Azide → 2-Azido-1-(4-nitrophenyl)ethanone

HRID 28596

反応式

HRID 28596 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=[O:4].[N-:14]=[N+:15]=[N-:16].[Na+]>O1CCCC1.C(O)C.O>[N:14]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=[O:4])=[N+:15]=[N-:16]

参加物

6

反応物 2

HCID 33557Sodium AzideHCID 668402-Bromo-4'-nitroacetophenone

生成物 1

HCID 167492572-Azido-1-(4-nitrophenyl)ethanone

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a mixture of 2-bromo-1-(4-nitro-phenyl)-ethanone (2.0 g, 8.2 mmol) in tetrahydrofuran (15 ml) and ethanol (15 ml) was added a solution of sodium azide (586 mg, 9.8 mmol) in water (1.5 ml). After stirring for 20 minutes, the mixture was concentrated under reduced pressure. The residue was treated with saturated aqueous sodium chloride solution (200 ml) and extracted with ethyl acetate (200 ml). The organic layer was dried over magnesium sulfate and concentrated under reduced pressure to give crude 2-azido-1-(4-nitrophenyl)-ethanone.

後処理

  1. concentrationthe mixture was concentrated under reduced pressure
  2. additionThe residue was treated with saturated aqueous sodium chloride solution (200 ml)
  3. extractionextracted with ethyl acetate (200 ml)
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-5782194270b84c77a8c805d693f2ce3c
出典データセット
uspto-grants-2008_09
特許番号
US07419984B2

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