4-Anilino-3-nitrobenzoic acid → 3-Amino-4-phenylamino-benzoic acid

HRID 28664

反応式

HRID 28664 の反応式
[NH:1]([C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=1[N+:17]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.[Pd]>[NH2:17][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:8]=1[NH:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:12]([OH:14])=[O:13]

参加物

4

反応物 1

HCID 38243664-Anilino-3-nitrobenzoic acid

生成物 1

HCID 7738213-Amino-4-phenylamino-benzoic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of the 4-anilino-3-nitrobenzoic acid (20.1 mmol) in THF (100 mL) was charged with 10% Pd/C (500 mg) and the reaction flask evacuated and subsequently charged with H2 (g) three times. The mixture was stirred vigorously for 12 h after which time it was filtered through diatomaceous earth and the filtrate concentrated in vacuo to give the desired 3-amino-4-anilinobenzoic acid: e.g. 3-amino4-[(3-hydroxyphenyl)amino]benzoic acid.

後処理

  1. customthe reaction flask evacuated
  2. additionsubsequently charged with H2 (g) three times
  3. filtrationwas filtered through diatomaceous earth
  4. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-0a653020fe1a4d3f9a6e01a5511e2f2e
出典データセット
uspto-grants-2008_09
特許番号
US07419995B2

関連ノート

読み込み中…