Sodium Hydroxide → Sodium 5-chloro-1,3-benzothiazole-2-carboxylate

HRID 29445ノート

反応式

HRID 29445 の反応式
C([O:3][C:4]([C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:9]=2[N:10]=1)=[O:5])C.[OH-].[Na+:17]>C1COCC1>[Na+:17].[Cl:15][C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([C:4]([O-:5])=[O:3])=[N:10][C:9]=2[CH:11]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 63357893Ethyl 5-chloro-1,3-benzothiazole-2-carboxylate

生成物 1

HCID 68717138Sodium 5-chloro-1,3-benzothiazole-2-carboxylate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To 5-chloro-benzothiazole-2-carboxylic acid ethyl ester (200 mg, 0.83 mmol) was added 3 mL of THF, and 0.83 mL (2 eq) of NaOH solution (2N in MeOH). The reaction mixture was stirred at room temperature overnight. The suspension was filtered and the solid was dried under vacuum to give 170 mg of 5-chloro-benzothiazole-2-carboxylic acid sodium salt as an off-white solid.

後処理

  1. filtrationThe suspension was filtered
  2. customthe solid was dried under vacuum

出典と根拠

ORDレコード
ord-fc3d1e80ce71433185d60e5556f9662d
出典データセット
uspto-grants-2008_09
特許番号
US07420001B2

反応ノート

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