2-Phenylisobutyric acid → 2-Methyl-2-phenylpropanoyl chloride

HRID 29517

反応式

HRID 29517 の反応式
[CH3:1][C:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:6])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:16])=O>ClCCl>[CH3:1][C:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:6])[C:3]([Cl:16])=[O:4]

参加物

4

反応物 2

HCID 132222-Phenylisobutyric acidHCID 65578Oxalyl chloride

生成物 1

HCID 123690862-Methyl-2-phenylpropanoyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-Methyl-2-phenylpropionic acid (10 mmol, 1.0 eq.) and oxalyl chloride (40 mmol, 4.0 eq.) in dichloromethane (30 mL) was stirred at room temperature for 18 h. The mixture was concentrated in vacuo to afford the title compound as a yellow oil.

後処理

  1. concentrationThe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-b388f55835f0450eb8040b6671d8a7a3
出典データセット
uspto-grants-2008_09
特許番号
US07420055B2

関連ノート

読み込み中…