Benzyl Bromide → 2-Benzylcaprolactone
反応式
[C:1]1(=[O:8])[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Li+].CC([N-]C(C)C)C.[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1COCC1.CN1C(=O)N(C)CCC1>[CH2:17]([CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:1]1=[O:8])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1参加物
6
実験手順
A solution of 1 mmol of caprolactone in 0.5 mL THF was added to a solution of LDA in 0.5 mL THF at -78° C. and this stirred for 2 h. Then a solution of 1.1 mmol of a benzylbromide in 0.14 mL DMPU was added to the above mixture and after stirring for 1 h at -15° C., the 2-benzylcaprolactone was isolated by extraction and chromatography.
後処理
- stirringafter stirring for 1 h at -15° C.
出典と根拠
- ORDレコード
- ord-1c2ee4b9716b4027b28c9669b15472c1
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731432
反応ノート
読み込み中…