Tert-Butylamine → N-tert-Butyl-N-(trimethylsilylmethyl)amine

HRID 29721

反応式

HRID 29721 の反応式
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].Cl[CH2:7][Si:8]([CH3:11])([CH3:10])[CH3:9].[OH-].[Na+]>>[C:1]([NH:5][CH2:7][Si:8]([CH3:11])([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 3

HCID 6385Tert-ButylamineHCID 14798Sodium HydroxideHCID 75361Silane, (chloromethyl)trimethyl-

生成物 1

HCID 425246N-tert-Butyl-N-(trimethylsilylmethyl)amine

反応条件

温度
200 °C

実験手順

A mixture of tert-butylamine (18.0 mL, 171 mmol) and (chloromethyl)trimethylsilane (7.00 g, 57.1 mmol) was heated in a thick-walled glass tube at 200° C. overnight. After cooling to ambient temperature, the reaction mixture was poured into 1 N NaOH and extracted three times with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4), and the volatiles evaporated in vacuo. Distillation (atmospheric pressure; ˜135° C.) of the residual liquid gave the title compound 77 as a colorless liquid.

後処理

  1. temperatureAfter cooling to ambient temperature
  2. extractionextracted three times with diethyl ether
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried (MgSO4)
  5. customthe volatiles evaporated in vacuo
  6. distillationDistillation (atmospheric pressure; ˜135° C.) of the residual liquid

出典と根拠

ORDレコード
ord-043b0c3cc51046faa4d80dcc8ff53bfc
出典データセット
uspto-grants-2008_09
特許番号
US07419990B2

関連ノート

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