Tert-Butylamine → N-tert-Butyl-N-(trimethylsilylmethyl)amine
反応式
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].Cl[CH2:7][Si:8]([CH3:11])([CH3:10])[CH3:9].[OH-].[Na+]>>[C:1]([NH:5][CH2:7][Si:8]([CH3:11])([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2]参加物
4
反応条件
- 温度
- 200 °C
実験手順
A mixture of tert-butylamine (18.0 mL, 171 mmol) and (chloromethyl)trimethylsilane (7.00 g, 57.1 mmol) was heated in a thick-walled glass tube at 200° C. overnight. After cooling to ambient temperature, the reaction mixture was poured into 1 N NaOH and extracted three times with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4), and the volatiles evaporated in vacuo. Distillation (atmospheric pressure; ˜135° C.) of the residual liquid gave the title compound 77 as a colorless liquid.
後処理
- temperatureAfter cooling to ambient temperature
- extractionextracted three times with diethyl ether
- washThe combined organic extracts were washed with brine
- dry with materialdried (MgSO4)
- customthe volatiles evaporated in vacuo
- distillationDistillation (atmospheric pressure; ˜135° C.) of the residual liquid
出典と根拠
- ORDレコード
- ord-043b0c3cc51046faa4d80dcc8ff53bfc
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07419990B2
反応ノート
読み込み中…