Tetrahydrofuran → 6-Bromohexyl cinnamate
反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8].C1COCC1.[C:14](Cl)(=[O:23])[CH:15]=[CH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(N(CC)CC)C>[C:14]([O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][Br:1])(=[O:23])[CH:15]=[CH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1参加物
5
実験手順
7 g of 6-bromohexanol was dissolved in a mixed solution of 5 ml of triethylamine as base and 50 ml of THF, and then, cinnamoyl chloride was added dropwise thereto at 0° C. The resultant was filtered to remove the solvent and the residue was purified with a SiO2 column chromatography (EA:n-Hexane=1:5) to obtain 8 g of 6-bromohexyl cinnamate (yield: 53%).
後処理
- customat 0° C
- filtrationThe resultant was filtered
- customto remove the solvent
- customthe residue was purified with a SiO2 column chromatography (EA:n-Hexane=1:5)
出典と根拠
- ORDレコード
- ord-6c427d124c894c5b946a8d05df74ed6e
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07422778B2
反応ノート
読み込み中…