3-Iodo-4-methylbenzaldehyde → 3-Iodo-4-methylstyrene

HRID 2974

反応式

HRID 2974 の反応式
[I:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH3:10])[CH:5]=O.[Li][CH2:12]CCC>[Br-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1COCC1>[I:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH3:10])[CH:5]=[CH2:12]

参加物

5

反応物 2

HCID 123302543-Iodo-4-methylbenzaldehydeHCID 178418339Butyllithium

生成物 1

HCID 196884243-Iodo-4-methylstyrene

試薬・触媒・溶媒 2

HCID 74505Methyltriphenyliphosphonium bromide触媒HCID 8028Tetrahydrofuran溶媒

実験手順

This aldehyde (1 mmol)was added to a premixed solution of 1.5 mmol of methyl triphenylphosphonium bromide and 1.2 mmol of n-BuLi in 5 mL of THF at 0° C. and this mixture was stirred for 3-6 h at rt and then processed by extraction and chromatography to give 3-iodo-4-methylstyrene.

後処理

  1. extractionprocessed by extraction and chromatography

出典と根拠

ORDレコード
ord-e65eb05600a341c1a97cfb8e1984da81
出典データセット
uspto-grants-1998_03
特許番号
US05731432

関連ノート

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