Tetrahydrofuran → 2-Chloro-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid ethyl ester

反応式

[CH2:17]([Li:18])[CH2:19][CH2:20][CH3:21].[Cl:1][c:2]1[s:3][cH:4][c:5](-[c:7]2[cH:8][c:9]([C:13]([F:14])([F:15])[F:16])[cH:10][cH:11][cH:12]2)[n:6]1.[Cl:22][C:23](=[O:24])[O:25][CH2:26][CH3:27].[O:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1>>[Cl:1][c:2]1[s:3][c:4]([C:23](=[O:24])[O:25][CH2:26][CH3:27])[c:5](-[c:7]2[cH:8][c:9]([C:13]([F:14])([F:15])[F:16])[cH:10][cH:11][cH:12]2)[n:6]1